Background Physical activity has been associated with reduced oxidative stress (OS) in
observational studies and clinical trials. Objective The purpose of this systematic review and …

Significance: Iron accumulation occurs in the central nervous system (CNS) in a variety of
neurological conditions as diverse as spinal cord injury, stroke, multiple sclerosis …

Traumatic spinal cord injury is a devastating insult followed by progressive cord atrophy and
neurodegeneration. Dysregulated or non-resolving inflammatory processes can disturb …

Key points Recent studies have indicated that antioxidant supplementation may blunt
adaptations to exercise, such as mitochondrial biogenesis induced by endurance training …

Intervertebral disc degeneration (IVDD) is the most common contributor to low back pain
(LBP). Recent studies have found that oxidative stress and reactive oxygen species (ROS) …

We show that redox active iron can induce a regulated form of non-apoptotic cell death and
tissue damage called ferroptosis that can contribute to secondary damage and functional …

Many preclinical studies in critical care medicine and related disciplines rely on hypothesis-
driven research in mice. The underlying premise posits that mice sufficiently emulate …

The aim of this study was to investigate the effects of vitamin C and E supplementation on
changes in muscle mass (lean mass and muscle thickness) and strength during 12 weeks of …

Affecting approximately 17,000 new people each year, spinal cord injury (SCI) is a
devastating injury that leads to permanent paraplegia or tetraplegia. Current …

Inflammation is a primary component of the central nervous system injury response.
Traumatic brain and spinal cord injury are characterized by a pronounced microglial …