Platelet-derived growth factor (PDGF) exerts its stimulatory effects on cell growth and motility
by binding to two related protein tyrosine kinase receptors. Ligand binding induces receptor …

Since its discovery over three decades ago, platelet-derived growth factor (PDGF) has been
a model system for learning how growth factors regulate biological processes. For the first …

Integrin‐mediated cell attachment modulates growth responses and growth factors regulate
cell attachment. Moreover, both cell attachment to extracellular matrix and mitogenic …

Caspases are activated during apoptosis and cleave specific proteins, resulting in the
irreversible commitment to cell death. The signal transduction proteins MEKK1, p21 …

We sought to explore the relationship between receptor tyrosine kinase (RTK) activated
signaling pathways and the transcriptional induction of immediate early genes (IEGs). Using …

Characteristic of chronic myelogenous leukemia (CML) is the presence of the chimeric p210
bcr-abl protein possessing elevated protein tyrosine kinase activity relative to normal c-abl …

Tyrosine kinase oncogenes are formed as a result of mutations that induce constitutive
kinase activity. Many of these tyrosine kinase oncogenes that are derived from genes, such …

The stimulation of platelet-derived growth factor (PDGF) receptors shifts vascular smooth
muscle (VSM) cells toward a more proliferative phenotype. Thrombin activates the same …

Vav proteins are guanine nucleotide exchange factors for Rho family GTPases which
activate pathways leading to actin cytoskeletal rearrangements and transcriptional …

Because the protein-tyrosine phosphatase (PTP) Syp associates with the tyrosine-
phosphorylated platelet-derived growth factor β receptor (βPDGFR), the βPDGFR is a likely …