A hypothesis on the evolutionary origin of the genetic pathway of sex determination in the
nematode Caenorhabditis elegans is presented here. It is suggested that the pathway arose …

The discovery that the primary transcripts of many genes are processed to produce more
than one kind of messenger RNA focuses attention on the control of RNA processing as a …

Fruit flies of the genus Drosophila have been an attractive and effective genetic model
organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them …

Two cDNAs were isolated whose dimerized products bind specifically to a DNA sequence,
KEY, located in the immunoglobulin kappa chain enhancer. Both cDNAs share a region of …

The doublesex (dsx) gene regulates somatic sexual differentiation in both sexes in D.
melanogaster. Two functional products are encoded by dsx: one product is expressed in …

This book will give an overview of insect ovaries, showing the diversities and the common
traits in egg growth processes. The idea to write this book developed while looking at the …

The transformer (fra) gene regulates female somatic sexual differentiation and has no known
function in males. It gives rise to two sizes of RNA, one non-sexspecific and one female …

Summary The gene transformer-2 (fra. 2) of Drosophila is necessary not Only for female
sexual differentiation but also for normal spermatogenesia in males. We have cloned and …

Sex-specific alternative splicing of RNA from the Drosophila fransformer gene involves
competition between two 3'splice sites. In the absence of Sex-lethal activity (as in males) …

The transformer(Pa) and doublesex (dsx) genes produce sex-specific transcripts that are
generated by differential RNA processing. We have examined the effects of mutants in other …