Beyond erectile dysfunction: cGMP-specific phosphodiesterase 5 inhibitors for other clinical disorders

A Samidurai, L Xi, A Das… - Annual review of …, 2023 - annualreviews.org
Cyclic guanosine monophosphate (cGMP), an important intracellular second messenger,
mediates cellular functional responses in all vital organs. Phosphodiesterase 5 (PDE5) is …

[HTML][HTML] Doxorubicin induced heart failure: Phenotype and molecular mechanisms

MA Mitry, JG Edwards - IJC heart & vasculature, 2016 - Elsevier
Long term survival of childhood cancers is now more than 70%. Anthracyclines, including
doxorubicin, are some of the most efficacious anticancer drugs available. However, its use …

Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease

RG Gourdie, S Dimmeler, P Kohl - Nature reviews Drug discovery, 2016 - nature.com
Our understanding of the functions of cardiac fibroblasts has moved beyond their roles in
heart structure and extracellular matrix generation and now includes their contributions to …

Current advances of nitric oxide in cancer and anticancer therapeutics

J Mintz, A Vedenko, O Rosete, K Shah, G Goldstein… - Vaccines, 2021 - mdpi.com
Nitric oxide (NO) is a short-lived, ubiquitous signaling molecule that affects numerous critical
functions in the body. There are markedly conflicting findings in the literature regarding the …

Protective role of melatonin in cardiac ischemia‐reperfusion injury: From pathogenesis to targeted therapy

H Zhou, Q Ma, P Zhu, J Ren, RJ Reiter… - Journal of pineal …, 2018 - Wiley Online Library
Acute myocardial infarction (MI) is a major cause of mortality and disability worldwide. In
patients with MI, the treatment option for reducing acute myocardial ischemic injury and …

Dual-target inhibitors based on HDACs: novel antitumor agents for cancer therapy

T Liu, Y Wan, Y Xiao, C Xia, G Duan - Journal of medicinal …, 2020 - ACS Publications
Histone deacetylases (HDACs) play an important role in regulating target gene expression.
They have been highlighted as a novel category of anticancer targets, and their inhibition …

Hydrogen sulfide, an enhancer of vascular nitric oxide signaling: mechanisms and implications

C Szabo - American Journal of Physiology-Cell Physiology, 2017 - journals.physiology.org
Nitric oxide (NO) vascular signaling has long been considered an independent, self-
sufficient pathway. However, recent data indicate that the novel gaseous mediator, hydrogen …

Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets

Y Zhao, W Xiong, C Li, R Zhao, H Lu, S Song… - … and Targeted Therapy, 2023 - nature.com
Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …

Metabolism and chronic inflammation: the links between chronic heart failure and comorbidities

Z Li, H Zhao, J Wang - Frontiers in Cardiovascular Medicine, 2021 - frontiersin.org
Heart failure (HF) patients often suffer from multiple comorbidities, such as diabetes, atrial
fibrillation, depression, chronic obstructive pulmonary disease, and chronic kidney disease …

Cardiomyopathy associated with diabetes: the central role of the cardiomyocyte

T Filardi, B Ghinassi, A Di Baldassarre… - International journal of …, 2019 - mdpi.com
The term diabetic cardiomyopathy (DCM) labels an abnormal cardiac structure and
performance due to intrinsic heart muscle malfunction, independently of other vascular co …