Over the years, click and bioorthogonal reactions have been the subject of considerable
research efforts. These high-performance chemical reactions have been developed to meet …

Cell-based therapy holds great potential to address unmet medical needs and revolutionize
the healthcare industry, as demonstrated by several therapeutics such as CAR-T cell …

Traditionally, organic chemical reactions require organic solvents, toxic catalysts, heat, or
high pressure. However, copper‐free click chemistry has been shown to have favorable …

Despite exosome promise as endogenous drug delivery vehicles, the current understanding
of exosome may be insufficient to develop their various applications. Here we synthesized …

Bottom‐up tissue engineering is a promising approach for designing modular biomimetic
structures that aim to recapitulate the intricate hierarchy and biofunctionality of native human …

Bioorthogonal click chemistry, first introduced in the early 2000s, has become one of the
most widely used approaches for designing advanced biomaterials for applications in tissue …

Bioorthogonal chemistry reactions occur in physiological conditions without interfering with
normal physiological processes. Through metabolic engineering, bioorthogonal groups can …

Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins,
and other molecules, and has been used in many research fields because of its beneficial …

Metabolic glycoengineering (MGE) is a technique for manipulating cellular metabolism to
modulate glycosylation. MGE is used to increase the levels of natural glycans and, more …

Bioorthogonal chemistry involves selective biocompatible reactions between functional
groups that are not normally present in biology. It has been used to probe biomolecules in …