VARIDT 2.0: structural variability of drug transporter

T Fu, F Li, Y Zhang, J Yin, W Qiu, X Li, X Liu… - Nucleic Acids …, 2022 - academic.oup.com
The structural variability data of drug transporter (DT) are key for research on precision
medicine and rational drug use. However, these valuable data are not sufficiently covered …

AI-driven GPCR analysis, engineering, and targeting

JPL Velloso, AS Kovacs, DEV Pires… - Current Opinion in …, 2024 - Elsevier
This article investigates the role of recent advances in Artificial Intelligence (AI) to
revolutionise the study of G protein-coupled receptors (GPCRs). AI has been applied to …

Multi-omics approach to identifying isoform variants as therapeutic targets in cancer patients

TI Shaw, B Zhao, Y Li, H Wang, L Wang… - Frontiers in …, 2022 - frontiersin.org
Cancer-specific alternatively spliced events (ASE) play a role in cancer pathogenesis and
can be targeted by immunotherapy, oligonucleotide therapy, and small molecule inhibition …

Sequence coevolution and structure stabilization modulate olfactory receptor expression

S Ghosh, CA de March, S Branciamore, S Kaleem… - Biophysical …, 2022 - cell.com
Olfactory receptors (ORs) belong to class A G-protein coupled receptors (GPCRs) and are
activated by a variety of odorants. To date, there is no three-dimensional structure of an OR …

Ten Years of GPCR Structures

MA Hanson, MC Orencia - GPCRs as Therapeutic Targets, 2022 - Wiley Online Library
Over the last two decades, tremendous efforts have focused on obtaining structural
information for G‐protein coupled receptors, one of the most sought‐after families of …

[PDF][PDF] Quantumzyme LLP, Krishnappa Layout, Lalbagh Road, Bangalore-560027, Karnataka, India. Department of Biotechnology & Bioinformatics 2, Faculty of Life …

KT Raj, A Singh, N Kulkarni, TS Gopenath - researchgate.net
Protein-protein, as well as protein-substrate interactions, play an important role in regulating
specific biological functions like signal transduction, apoptosis, gene regulation, and …