Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …

Simple Summary Drug resistance remains one of the major problems in cancer therapy and
is responsible for up to 90% of cancer-related deaths. It exists across all types of cancer and …

The multidrug resistance phenomenon presents a major threat to the pharmaceutical
industry. This resistance is a common occurrence in several diseases and is mediated by …

Multidrug resistance (MDR) is a serious phenomenon employed by cancer cells which
hampers the success of cancer pharmacotherapy. One of the common mechanisms of MDR …

Drug resistance has compromised the efficacy of chemotherapy. The dysregulation of drug
transporters including P-glycoprotein (P-gp) can mediate drug resistance through drug …

Noncoding RNAs (ncRNAs) represent a large segment of the human transcriptome and
have been shown to play important roles in cellular physiology and disease pathogenesis …

Pharmacokinetics (PK) is the study of the absorption, distribution, metabolism, and excretion
(ADME) processes of a drug. Understanding PK properties is essential for drug development …

Acute myeloid leukemia (AML) is a malignant tumor of the immature myeloid hematopoietic
cells in the bone marrow (BM). It is a highly heterogeneous disease, with rising morbidity …

Multidrug resistance (MDR) remains a major clinical obstacle to successful cancer treatment.
Although diverse mechanisms of MDR have been well elucidated, such as dysregulation of …

Small noncoding RNAs, as post-translational regulators of many target genes, are not only
markers of neoplastic disease initiation and progression, but also markers of response to …