Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …

Synapses enable neurons to communicate with each other and are therefore a prerequisite
for normal brain function. Presynaptically, this communication requires energy and …

An important concept in neurobiology is “neurons that fire together, wire together” which
means that the formation and maintenance of synapses is promoted by activation of those …

Neurodegenerative diseases (NDs) result from progressive deterioration of selectively
susceptible neuron populations in different central nervous system (CNS) regions. NDs are …

Cockayne syndrome (CS) is a disorder characterized by a variety of clinical features
including cachectic dwarfism, severe neurological manifestations including microcephaly …

Mitochondrial remodeling is dysregulated in metabolic diseases but the underlying
mechanism is not fully understood. We report here that BDNF (brain derived neurotrophic …

Synaptic plasticity in the adult brain is believed to represent the cellular mechanisms of
learning and memory. Mitochondria are involved in the regulation of the complex processes …

Mitochondria are dynamic organelles that undergo transport, fission, and fusion. The three
main functions of mitochondria are to generate ATP, buffer cytosolic calcium, and generate …

Long-lasting changes of brain function in response to experience rely on diverse forms of
activity-dependent synaptic plasticity. Chief among them are long-term potentiation and long …

Mitochondria in neurons, in addition to their primary role in bioenergetics, also contribute to
specialized functions, including regulation of synaptic transmission, Ca2+ homeostasis …