Interplanetary exploration will be humankind's most ambitious expedition and the journey
required to do so, is as intimidating as it is intrepid. One major obstacle for successful deep …

The naturally occurring polyphenol phytoalexin resveratrol (RSV) regulates neuronal
inflammation in various disease models and protects the brain against ischemic injury. Cell …

Dysfunction of glutamate transporters has been proposed to promote neuronal death in
modelled cerebral ischemia. However, these studies have produced conflicting results and …

Triterpenes comprise one of the most interesting groups of natural products due to their
diverse pharmacological activities. Triterpenes are ubiquitously present in variety of …

Energy depletion caused by ischemic brain insults may result in persistent neuronal
depolarization accompanied by hyper-stimulation of ionotropic glutamate receptors and …

Considerable evidence has been accumulated demonstrating an important role for
inflammation in ischemic brain injury and its contribution to greater cerebral damage after …

Synaptic dysfunction underlies cognitive deficits induced by chronic cerebral hypoperfusion
(CCH). There are silent synapses in neural circuits, but the effect of CCH on silent synapses …

The mechanisms of many diseases, including central nervous system disorders, are
regulated by circadian rhythms. The development of brain disorders such as depression …

We investigated the quantitative and morphofunctional alterations of neuron-astrocyte-
microglia triads in CA3 hippocampus, in comparison to CA1, after 2 Vessel Occlusion (2VO) …

Over-activation of AMPARs (α− amino-3-hydroxy-5-methylisoxazole-4-propionic acid
subtype glutamate receptors) is implicated in excitotoxic neuronal death associated with …