Biomolecular engineering can be used to purposefully manipulate biomolecules, such as
peptides, proteins, nucleic acids and lipids, within the framework of the relations among their …

The influences of glycans impact all biological processes, disease states, and pathogenic
interactions. Glycan-binding proteins (GBPs), such as lectins, are decisive tools for …

Cleft palate is a common major birth defect for which currently known causes account for
less than 30% of pathology in humans. In this study, we carried out mutagenesis screening …

Lectins are a widespread group of sugar-binding proteins occurring in all types of organisms
including animals, plants, bacteria, fungi and even viruses. According to a recent report …

Glycosaminoglycan (GAG) is a polysaccharide present on the cell surface as an
extracellular matrix component, and is composed of repeating disaccharide units consisting …

Lectins are proteins that have the ability to recognize and bind in a reversible and specific
way to free carbohydrates or glycoconjugates of cell membranes. For these reasons, they …

Protein–carbohydrate interactions underlie essential biological processes. Elucidating the
mechanism of protein–carbohydrate recognition is a prerequisite for modeling and …

Late-onset non-syndromic autosomal dominant hearing loss 9 (DFNA9) is a hearing
impairment caused by mutations in the coagulation factor C homology gene (COCH). COCH …

HIV/AIDS has become a worldwide pandemic. Before an effective HIV-1 vaccine eliciting
broadly neutralizing monoclonal antibodies (bnmAbs) is fully developed, passive …

Concanavalin A (ConA), a mannose (Man)‐specific leguminous lectin isolated from the jack
bean (Canavalia ensiformis) seed extracts, was discovered over a century ago. Although …