Neurodegenerative disorders like Parkinson's disease, Alzheimer's disease, or amyotrophic
lateral sclerosis are affecting a rapidly increasing population worldwide. While common …

Axons in the peripheral nervous system have the ability to repair themselves after damage,
whereas axons in the central nervous system are unable to do so. A common and important …

Rho kinase (ROCK) is a serine/threonine kinase and a downstream target of the small
GTPase Rho. The RhoA/ROCK pathway is associated with various neuronal functions such …

Growth cones, found at the tip of axonal projections, are the sensory and motile organelles
of developing neurons that enable axon pathfinding and target recognition for precise wiring …

Abstract The Rho/ROCK/LIMK pathway is central for the mediation of repulsive
environmental signals in the central nervous system. Several studies using pharmacological …

In a variety of normal and pathological cell types, Rho-kinases I and II (ROCKI/II) play a
pivotal role in the organization of the nonmuscle and smooth muscle cytoskeleton and …

Parkinson's disease (PD) is the most common neurodegenerative movement disorder, yet
disease-modifying treatments do not currently exist. Rho-associated protein kinase (ROCK) …

Axonal degeneration is one of the earliest features of Parkinson's disease pathology, which
is followed by neuronal death in the substantia nigra and other parts of the brain. Inhibition …

Degeneration of the axon is an important step in the pathomechanism of traumatic,
inflammatory and degenerative neurological diseases. Increasing evidence suggests that …

Disease progression in amyotrophic lateral sclerosis (ALS) is characterized by degeneration
of motoneurons (MN) and their axons, but is also influenced by neighboring cells such as …