Actions of thyroid hormones and thyromimetics on the liver
Thyroid hormones (triiodothyronine and thyroxine) are pivotal for metabolic balance in the
liver and entire body. Dysregulation of the hypothalamus–pituitary–thyroid axis can …
liver and entire body. Dysregulation of the hypothalamus–pituitary–thyroid axis can …
The aging thyroid: a reappraisal within the geroscience integrated perspective
C Franceschi, R Ostan, S Mariotti, D Monti… - Endocrine …, 2019 - academic.oup.com
The thyroid plays a crucial and pervasive role in physiology (metabolism, thermogenesis,
and immunity, among others) and its aging and related changes in thyroid hormone …
and immunity, among others) and its aging and related changes in thyroid hormone …
Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism
Y Yan, Z Niu, C Sun, P Li, S Shen, S Liu, Y Wu… - Nature …, 2022 - nature.com
Thyroid hormones (TH) regulate systemic glucose metabolism through incompletely
understood mechanisms. Here, we show that improved glucose metabolism in hypothyroid …
understood mechanisms. Here, we show that improved glucose metabolism in hypothyroid …
Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function
Thyroid hormone receptor β1 (THRB1) and estrogen-related receptor α (ESRRA; also
known as ERRα) both play important roles in mitochondrial activity. To understand their …
known as ERRα) both play important roles in mitochondrial activity. To understand their …
The hepatokine Tsukushi gates energy expenditure via brown fat sympathetic innervation
Thermogenesis is an important contributor to whole-body energy expenditure and metabolic
homeostasis. Although circulating factors that promote energy expenditure are known …
homeostasis. Although circulating factors that promote energy expenditure are known …
A clinician's guide to understanding resistance to thyroid hormone due to receptor mutations in the TRα and TRβ isoforms
There are two genes that express the major thyroid hormone receptor isoforms. Mutations in
both these genes have given rise to Resistance to Thyroid Hormone (RTH) syndromes …
both these genes have given rise to Resistance to Thyroid Hormone (RTH) syndromes …
DNA methylation in autoimmune thyroid disease
N Lafontaine, SG Wilson… - The Journal of Clinical …, 2023 - academic.oup.com
Graves disease and Hashimoto disease form part of the spectrum of autoimmune thyroid
disease (AITD), to which genetic and environmental factors are recognized contributors …
disease (AITD), to which genetic and environmental factors are recognized contributors …
Parechovirus A pathogenesis and the enigma of genotype A-3
Parechovirus A is a species in the Parechovirus genus within the Picornaviridae family that
can cause severe disease in children. Relatively little is known on Parechovirus A …
can cause severe disease in children. Relatively little is known on Parechovirus A …
Novel transcriptional mechanisms for regulating metabolism by thyroid hormone
The thyroid hormone plays a key role in energy and nutrient metabolisms in many tissues
and regulates the transcription of key genes in metabolic pathways. It has long been …
and regulates the transcription of key genes in metabolic pathways. It has long been …