Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

It is generally regarded that the progression of an infection within host macrophages is the
consequence of a failed immune response. However, recent appreciation of macrophage …

As they proliferate, fungi expose antigens at their cell surface that are potent stimulators of
the innate immune response, and yet the commensal fungus Candida albicans is able to …

Metabolism is integral to the pathogenicity of Candida albicans, a major fungal pathogen of
humans. As well as providing the platform for nutrient assimilation and growth in diverse …

Candida albicans is an opportunistic fungal pathogen that is found in the normal
gastrointestinal flora of most healthy humans. However, under certain environmental …

The mammalian gastrointestinal tract and bloodstream are highly disparate biological
niches that differ in concentrations of nutrients such as iron. However, some commensal …

ABSTRACT pH homeostasis is critical for all organisms; in the fungal pathogen Candida
albicans, pH adaptation is critical for virulence in distinct host niches. We demonstrate that …

The survival of all microbes depends upon their ability to respond to environmental
challenges. To establish infection, pathogens such as C andida albicans must mount …

Deadly infections from opportunistic fungi have risen in frequency, largely because of the at-
risk immunocompromised population created by advances in modern medicine and the …

Only few Candida species, eg, Candida albicans, Candida glabrata, Candida dubliniensis,
and Candida parapsilosis, are successful colonizers of a human host. Under certain …