Inferring structural variant cancer cell fraction
We present SVclone, a computational method for inferring the cancer cell fraction of
structural variant (SV) breakpoints from whole-genome sequencing data. SVclone …
structural variant (SV) breakpoints from whole-genome sequencing data. SVclone …
Assessing reliability of intra-tumor heterogeneity estimates from single sample whole exome sequencing data
Tumors are made of evolving and heterogeneous populations of cells which arise from
successive appearance and expansion of subclonal populations, following acquisition of …
successive appearance and expansion of subclonal populations, following acquisition of …
CloneSig can jointly infer intra-tumor heterogeneity and mutational signature activity in bulk tumor sequencing data
Systematic DNA sequencing of cancer samples has highlighted the importance of two
aspects of cancer genomics: intra-tumor heterogeneity (ITH) and mutational processes …
aspects of cancer genomics: intra-tumor heterogeneity (ITH) and mutational processes …
Model-based tumor subclonal reconstruction
The vast majority of cancer next-generation sequencing data consist of bulk samples
composed of mixtures of cancer and normal cells. To study tumor evolution, subclonal …
composed of mixtures of cancer and normal cells. To study tumor evolution, subclonal …
The inter and intra-tumoural heterogeneity of subclonal reconstruction
V Bhandari, LY Liu, A Salcedo, SMG Espiritu… - bioRxiv, 2018 - biorxiv.org
Background Each tumour is a community of cells related through a common ancestry. Each
cell in this community faces a slightly different set of selective pressures, and evolves at least …
cell in this community faces a slightly different set of selective pressures, and evolves at least …
CloneSig: joint inference of intra-tumor heterogeneity and mutational signatures' activity in tumor bulk sequencing data
The possibility to sequence DNA in cancer samples has triggered much effort recently to
identify the forces at the genomic level that shape tumorigenesis and cancer progression. It …
identify the forces at the genomic level that shape tumorigenesis and cancer progression. It …
The promise and perils of sequencing individual prostate cancer nuclei
PC Boutros - European urology, 2018 - pubmed.ncbi.nlm.nih.gov
Statistical methods for deciphering intra-tumor hereterogeneity: challenges and opportunities for cancer clinical management
J Abecassis - 2020 - pastel.hal.science
Accessing the repertoire of cancer somatic alterations has been instrumental in our current
understanding of carcinogenesis. However, efforts in genomic characterization of cancers …
understanding of carcinogenesis. However, efforts in genomic characterization of cancers …