Adeno-associated viruses (AAV) are ubiquitous in the human population (> 90% of adults
are seropositive) but have never been implicated as the cause of any disease. They were …

Several techniques have been devised for the dissociation of tissues for primary culture.
These techniques can affect the quantity and quality of the isolated cells. The aim of our …

Objective and Design: As acute inflammation is known to cause a reduction in hepatic P-
Glycoprotein (PGP) expression and activity in rats, we tested the hypothesis that the pro …

Peroxisome proliferation is a phenomenon occurring when responsive animals are exposed
to certain compounds so-called peroxisome proliferators and is regulated through a nuclear …

In the presence of phenobarbital (PB) at 3 mM, hepatocytes isolated from adult rats by a
collagenase-perfusion technique survived well on plastic dishes for at least 49 days after …

Cell viability, cytochrome P-450 content, cell respiration, and lipid peroxidation were all
investigated as a function of oxygen tension in adult rat hepatocytes in short-term culture …

Abstract Possible roles of dibutyryladenosine 3′, 5′-cyclic monophosphate (cAMP) and
dibutyrylguanosine 3′, 5′-cyclic monophosphate (cGMP) in regulation of hepatocyte DNA …

The mechanisms, by which phenobarbital (PB) supports the survival of adult rat hepatocytes
in primary culture, were investigated. PB altered the shape of rat erythrocytes to produce cup …

A technique is described for isolation of adult rat hepatocytes from micronodular cirrhotic
livers based on a collagenase digestion procedure. Hepatocytes from normal livers and …

For serum-free primary culture of adult rat hepatocytes, a synthetic medium DM-160 and rat-
tail collagen were selected for the basal medium and for the culture substratum, respectively …