Mechanisms of human lymphoid chromosomal translocations
MR Lieber - Nature Reviews Cancer, 2016 - nature.com
Abstract Analysis of chromosomal translocation sequence locations in human lymphomas
has provided valuable clues about the mechanism of the translocations and when they …
has provided valuable clues about the mechanism of the translocations and when they …
[HTML][HTML] RAG represents a widespread threat to the lymphocyte genome
The RAG1 endonuclease, together with its cofactor RAG2, is essential for V (D) J
recombination but is a potent threat to genome stability. The sources of RAG1 mis-targeting …
recombination but is a potent threat to genome stability. The sources of RAG1 mis-targeting …
Histone methylation and V (D) J recombination
N Shimazaki, MR Lieber - International journal of hematology, 2014 - Springer
Abstract V (D) J recombination is the process by which the diversity of antigen receptor
genes is generated and is also indispensable for lymphocyte development. This …
genes is generated and is also indispensable for lymphocyte development. This …
RAG1 targeting in the genome is dominated by chromatin interactions mediated by the non-core regions of RAG1 and RAG2
Y Maman, G Teng, R Seth, SH Kleinstein… - Nucleic acids …, 2016 - academic.oup.com
The RAG1/RAG2 endonuclease initiates V (D) J recombination at antigen receptor loci but
also binds to thousands of places outside of these loci. RAG2 localizes directly to lysine 4 …
also binds to thousands of places outside of these loci. RAG2 localizes directly to lysine 4 …
Single-molecule analysis of RAG-mediated V (D) J DNA cleavage
The recombination-activating gene products, RAG1 and RAG2, initiate V (D) J
recombination during lymphocyte development by cleaving DNA adjacent to conserved …
recombination during lymphocyte development by cleaving DNA adjacent to conserved …
Real-time analysis of RAG complex activity in V (D) J recombination
J Zagelbaum, N Shimazaki… - Proceedings of the …, 2016 - National Acad Sciences
Single-molecule FRET (smFRET) and single-molecule colocalization (smCL) assays have
allowed us to observe the recombination-activating gene (RAG) complex reaction …
allowed us to observe the recombination-activating gene (RAG) complex reaction …
Recruitment of RAG1 and RAG2 to chromatinized DNA during V (D) J recombination
V (D) J recombination is initiated by the binding of the RAG1 and RAG2 proteins to
recombination signal sequences (RSSs) that consist of conserved heptamer and nonamer …
recombination signal sequences (RSSs) that consist of conserved heptamer and nonamer …
Epigenetic modifications of the VH region after DJH recombination in Pro‐B cells
Y Dong, C Wu, X Zhao, P Zhang, H Zhang… - …, 2017 - Wiley Online Library
The variable region of murine immunoglobulin heavy chain (Igh) is assembled by sequential
DH–JH and VH–DJH recombination. The accessibility of the Igh locus determines the order …
DH–JH and VH–DJH recombination. The accessibility of the Igh locus determines the order …
Origin of disease heterogeneity in BCR-ABL1 lymphoblastic leukemia
JC Kim - 2021 - search.proquest.com
BCR-ABL1 positive acute lymphoblastic leukemia (ALL) is an aggressive subtype of ALL
that commonly appears in adults. Introduction of tyrosine kinase inhibitors into frontline …
that commonly appears in adults. Introduction of tyrosine kinase inhibitors into frontline …
“Cut-and-Run”: A New Way By Which Aberrant V (D) J Recombination Causes Genome Instability
X Wang - 2018 - etheses.whiterose.ac.uk
V (D) J recombination is essential to create a highly diverse repertoire of antigen receptors.
However, this process carries an inherent risk because it involves breaking genomic DNA …
However, this process carries an inherent risk because it involves breaking genomic DNA …