Topography: a biophysical approach to direct the fate of mesenchymal stem cells in tissue engineering applications

X Cun, L Hosta-Rigau - Nanomaterials, 2020 - mdpi.com
Tissue engineering is a promising strategy to treat tissue and organ loss or damage caused
by injury or disease. During the past two decades, mesenchymal stem cells (MSCs) have …

Immunomodulation effect of biomaterials on bone formation

T Zhao, Z Chu, J Ma, L Ouyang - Journal of Functional Biomaterials, 2022 - mdpi.com
Traditional bone replacement materials have been developed with the goal of directing the
osteogenesis of osteoblastic cell lines toward differentiation and therefore achieving …

Osteogenesis of 3D printed porous Ti6Al4V implants with different pore sizes

Q Ran, W Yang, Y Hu, X Shen, Y Yu, Y Xiang… - Journal of the Mechanical …, 2018 - Elsevier
Selective laser melting (SLM) is one of the three-dimensional (3D) printing techniques that
manufacturing versatile porous scaffolds with precise architectures for potential orthopedic …

[HTML][HTML] High proportion strontium-doped micro-arc oxidation coatings enhance early osseointegration of titanium in osteoporosis by anti-oxidative stress pathway

X Shen, K Fang, KHR Yie, Z Zhou, Y Shen, S Wu… - Bioactive Materials, 2022 - Elsevier
The excessive accumulation of reactive oxygen species (ROS) under osteoporosis
precipitates a microenvironment with high levels of oxidative stress (OS). This could …

An improved osseointegration of metal implants by pitavastatin loaded multilayer films with osteogenic and angiogenic properties

W Chen, G Xie, Y Lu, J Wang, B Feng, Q Wang, K Xu… - Biomaterials, 2022 - Elsevier
An increasing number of works have highlighted the importance of metal implants surface
modification in enhancing bone defect healing through the synergistic osteogenesis …

Biofunctional elements incorporated nano/microstructured coatings on titanium implants with enhanced osteogenic and antibacterial performance

N Xu, J Fu, L Zhao, PK Chu… - Advanced Healthcare …, 2020 - Wiley Online Library
Bone fracture is prevalent among athletes and senior citizens and may require surgical
insertion of bone implants. Titanium (Ti) and its alloys are widely used in orthopedics due to …

Optimizing the strontium content to achieve an ideal osseointegration through balancing apatite-forming ability and osteogenic activity

Z Geng, S Sang, S Wang, F Meng, Z Li, S Zhu… - Biomaterials …, 2022 - Elsevier
Implant failure caused by unsatisfying osseointegration is still a noteworthy clinical problem.
Strontium (Sr) has been confirmed to be a bioactive element that facilitates bone growth. In …

Multilayered coating of titanium implants promotes coupled osteogenesis and angiogenesis in vitro and in vivo

W Chen, K Xu, B Tao, L Dai, Y Yu, C Mu, X Shen, Y Hu… - Acta biomaterialia, 2018 - Elsevier
We used surface-modified titanium (Ti) substrates with a multilayered structure composed of
chitosan-catechol (Chi-C), gelatin (Gel) and hydroxyapatite (HA) nanofibers, which were …

Gallium (Ga)–strontium (Sr) layered double hydroxide composite coating on titanium substrates for enhanced osteogenic and antibacterial abilities

K Li, H Tian, A Guo, L Jin, W Chen… - Journal of Biomedical …, 2022 - Wiley Online Library
Bacterial infection and poor osteogenic capacity can result in the loosing or failure of
titanium (Ti)‐based implants in the clinic. Therefore, it is urgent to design an effective …

The effects of Sr-incorporated micro/nano rough titanium surface on rBMSC migration and osteogenic differentiation for rapid osteointegration

C Zhou, A Xu, D Wang, G Lin, T Liu, F He - Biomaterials science, 2018 - pubs.rsc.org
Recruitment of endogenous bone marrow-derived mesenchymal stem cells (BMSCs) has
been widely discussed as an alternative strategy for bone regeneration. Strontium (Sr) is …