ISG15 and ISGylation in human diseases
O Mirzalieva, M Juncker, J Schwartzenburg, S Desai - Cells, 2022 - mdpi.com
Type I Interferons (IFNs) induce the expression of> 500 genes, which are collectively called
ISGs (IFN-stimulated genes). One of the earliest ISGs induced by IFNs is ISG15 (Interferon …
ISGs (IFN-stimulated genes). One of the earliest ISGs induced by IFNs is ISG15 (Interferon …
The functional roles of ISG15/ISGylation in cancer
Y Yuan, H Qin, H Li, W Shi, L Bao, S Xu, J Yin, L Zheng - Molecules, 2023 - mdpi.com
The protein ISG15 encoded by interferon-stimulated gene (ISG) 15 is the first identified
member of the ubiquitin-like protein family and exists in the form of monomers and …
member of the ubiquitin-like protein family and exists in the form of monomers and …
Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer
J Lothion-Roy, DB Haigh, AE Harris, VM Metzler… - Frontiers in …, 2023 - frontiersin.org
N6-methyladenosine (m6A) is the most abundant internal mRNA modification and is
dynamically regulated through distinct protein complexes that methylate, demethylate …
dynamically regulated through distinct protein complexes that methylate, demethylate …
A Listeria-based vaccine targeting ISG15 exerts anti-tumor efficacy in renal cell carcinoma
Renal cell carcinoma (RCC) is the deadliest form of urological cancer and is projected to be
the fourth most common neoplasm in the USA in males by 2040. In addition to the current …
the fourth most common neoplasm in the USA in males by 2040. In addition to the current …
Ubiquitin-conjugating enzyme 2C (UBE2C) is a poor prognostic biomarker in invasive breast cancer
Abstract Background The Ubiquitin-conjugating enzyme 2C (UBE2C) is essential for the
ubiquitin–proteasome system and is involved in cancer cell migration and apoptosis. This …
ubiquitin–proteasome system and is involved in cancer cell migration and apoptosis. This …
Genome-wide DNA methylation profiling of HPV-negative leukoplakia and gingivobuccal complex cancers
M Inchanalkar, S Srivatsa, S Ambatipudi, PG Bhosale… - Clinical …, 2023 - Springer
Background Gingivobuccal complex oral squamous cell carcinoma (GBC-OSCC) is an
aggressive malignancy with high mortality often preceded by premalignant lesions …
aggressive malignancy with high mortality often preceded by premalignant lesions …
The mRNA stability of NCAPG2, a novel contributor to breast invasive carcinoma, is enhanced by the RNA-binding protein PCBP2
S Han, X Jin, T Hu, F Chi - Cellular Signalling, 2023 - Elsevier
Non-SMC condensin II complex subunit G2 (NCAPG2) is one of the three non-SMC subunits
in condensin II, which plays a vital role in regulating chromosome condensation and …
in condensin II, which plays a vital role in regulating chromosome condensation and …
Unveiling the Multifaceted Roles of ISG15: From Immunomodulation to Therapeutic Frontiers
The Interferon Stimulated Gene 15 (ISG15), a unique Ubiquitin-like (Ubl) modifier exclusive
to vertebrates, plays a crucial role in the immune system. Primarily induced by interferon …
to vertebrates, plays a crucial role in the immune system. Primarily induced by interferon …
KIR2DL4 promotes the proliferation of RCC cell associated with PI3K/Akt signaling activation
XF Ding, J Chen, HL Ma, Y Liang, YF Wang, HT Zhang… - Life Sciences, 2022 - Elsevier
Background Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4) is a transmembrane
glycoprotein that is expressed by natural killer (NK) cells and certain subsets of T cells …
glycoprotein that is expressed by natural killer (NK) cells and certain subsets of T cells …
SNAT2/SLC38A2 confers the stemness of gastric cancer cells via regulating glutamine level
K Nie, M Cai - Digestive Diseases and Sciences, 2022 - Springer
Abstract Background Glutamine (Gln) is essential for cancer progression, however, few
studies have been conducted to investigate the roles of Gln transporters in gastric cancer …
studies have been conducted to investigate the roles of Gln transporters in gastric cancer …