Redox-dependent processes influence most cellular functions, such as differentiation,
proliferation, and apoptosis. Mitochondria are at the center of these processes, as …

In a complex system of interrelated reactions, the heart converts chemical energy to
mechanical energy. Energy transfer is achieved through coordinated activation of enzymes …

Oxidative damage from elevated production of reactive oxygen species (ROS) contributes to
ischemia-reperfusion injury in myocardial infarction and stroke. The mechanism by which …

A well-regulated redox state is essential for normal physiological function and cellular
metabolism. In most eukaryotic cells, protein cysteine thiols are most sensitive to fluctuations …

In the cardiovascular system, changes in oxidative balance can affect many aspects of
cellular physiology through redox-signaling. Depending on the magnitude, fluctuations in …

Significance: The mitochondrial matrix contains much of the machinery at the heart of
metabolism. This compartment is also exposed to a high and continual flux of superoxide …

Cell Science at a Glance 801 of a particular reactive oxygen species (ROS) or the shift in
redox state of a responsive group such as a dithiol–disulphide couple (D'Autreaux and …

Redox networks in the cell integrate signaling pathways that control metabolism, energetics,
cell survival, and death. The physiological second messengers that modulate these …

Cysteine occupies a unique place in protein chemistry. The nucleophilic thiol group allows
cysteine to undergo a broad range of redox modifications beyond classical thiol-disulfide …

There is an intimate interplay between cellular metabolism and the pathophysiology of
disease. Mitochondria are essential to maintaining and regulating metabolic function of cells …