Individual differences in cognitive performance increase with advancing age, reflecting
marked cognitive changes in some individuals along with little or no change in others …

Tauopathies are a heterogeneous group of neurodegenerative disorders that are
characterised by the aggregation of the microtubule-associated protein tau into filamentous …

Genome-wide association studies have discovered numerous genomic loci associated with
Alzheimer's disease (AD); yet the causal genes and variants are incompletely identified. We …

Prion‐like transcellular spreading of tau in Alzheimer's Disease (AD) is mediated by tau
binding to cell surface heparan sulfate (HS). However, the structural determinants for tau …

Background Growing evidence shows that epigenetic modifications play a role in
Alzheimer's disease (AD). We performed an epigenome-wide association study (EWAS) to …

Background Insulin resistance is suggested to have negative effects on cognition; however,
results from large population studies are lacking. In this study, the potential relationships …

An incomplete ascertainment of genetic variation within the highly polymorphic
immunoglobulin heavy chain locus (IGH) has hindered our ability to define genetic factors …

Background Genome-wide association studies have identified more than 30 Alzheimer's
disease (AD) risk genes, although the detailed mechanism through which all these genes …

Tauopathies are a heterogenous family of progressive neurodegenerative diseases defined
by the appearance of proteinaceous lesions within the brain composed of abnormally folded …

HS3ST1 is a genetic risk gene associated with Alzheimer's disease (AD) and overexpressed
in patients, but how it contributes to the disease progression is unknown. We report the …