Mechanisms of epigenetic regulation, including DNA methylation, chromatin remodeling,
and histone post-translational modifications, are involved in multiple aspects of neuronal …

Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …

Alzheimer's disease (AD) is the most common form of dementia and it is characterized by the
deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain. However, the …

Brain-derived neurotrophic factor (BDNF) influences the differentiation, plasticity, and
survival of central neurons and likewise, affects the development of the neuromuscular …

Assemblies of tau can transit between neurons, seeding aggregation in a prion-like manner.
To accomplish this, tau must cross cell-limiting membranes, a process that is poorly …

Enhancement of brain-derived neurotrophic factor (BDNF) signalling has great potential in
therapy for neurological and psychiatric disorders. This neurotrophin not only attenuates cell …

Brain-derived neurotrophic factor (BDNF) is involved in many functions such as neuronal
growth, survival, synaptic plasticity and memorization. Altered expression levels are …

Aging is associated with a progressive decline of brain function, and the underlying causes
and possible interventions to prevent this cognitive decline have been the focus of intense …

Cognitive decline is a hallmark of the aging nervous system, characterized by increasing
memory loss and a deterioration of mental capacity, which in turn creates a favorable context …

Neurobiological evidence suggests that the ketone metabolite β-hydroxybutyrate (BHBA)
exerts many neuroprotective functions for the brain. The previous study revealed that BHBA …