In the mid-1960s, bone morphogenetic proteins (BMPs) were first identified in the extracts of
bone to have the remarkable ability to induce heterotopic bone. When the Drosophila gene …

High concentration of cytoskeletal filaments, organelles, and proteins along with the space
constraints due to the axon's narrow geometry lead inevitably to intracellular physical …

Huntington's disease (HD) is characterized by protein inclusions and loss of striatal neurons
which result from expanded CAG repeats in the poly-glutamine (polyQ) region of the …

While post-transcriptional control is thought to be required at the periphery of neurons and
glia, its extent is unclear. Here, we investigate systematically the spatial distribution and …

TAR DNA-binding protein 43 (TDP-43) is genetically and functionally linked to amyotrophic
lateral sclerosis (ALS) and regulates transcription, splicing, and transport of thousands of …

Loss of huntingtin (HTT), the Huntington's disease (HD) protein, was previously shown to
cause axonal transport defects. Within axons, HTT can associate with kinesin-1 and dynein …

ABSTRACT HTT (huntingtin) is a 350-kDa protein of unknown function. While HTT moves
bidirectionally within axons and HTT loss/reduction causes axonal transport defects, the …

It is more than 25 years since the discovery that kinesin 1 is phosphorylated by several
protein kinases. However, fundamental questions still remain as to how specific protein …

Neurons require target‐derived autocrine and paracrine growth factors to maintain proper
identity, innervation, homeostasis and survival. Neuronal growth factor signaling is highly …

Proper transport of the Parkinson's disease (PD) protein, α-synuclein (α-syn), is thought to
be crucial for its localization and function at the synapse. Previous work has shown that …