Infectious Diseases Society of America 2023 guidance on the treatment of antimicrobial resistant gram-negative infections

PD Tamma, SL Aitken, RA Bonomo… - Clinical Infectious …, 2023 - academic.oup.com
Abstract Background The Infectious Diseases Society of America is committed to providing
up-to-date guidance on the treatment of antimicrobial-resistant infections. This guidance …

Antibiotic-resistant ESKAPE pathogens and COVID-19: the pandemic beyond the pandemic

A Catalano, D Iacopetta, J Ceramella, M Pellegrino… - Viruses, 2023 - mdpi.com
Antibacterial resistance is a renewed public health plague in modern times, and the COVID-
19 pandemic has rekindled this problem. Changes in antibiotic prescribing behavior …

[HTML][HTML] Nosocomial outbreak by NDM-1-producing Klebsiella pneumoniae highly resistant to cefiderocol, Florence, Italy, August 2021 to June 2022

M Coppi, A Antonelli, C Niccolai, A Bartolini… - …, 2022 - eurosurveillance.org
A nosocomial outbreak by cefiderocol (FDC)-resistant NDM-1-producing Klebsiella
pneumoniae (NDM-Kp) occurred in a large tertiary care hospital from August 2021–June …

Meropenem/vaborbactam: β-lactam/β-lactamase inhibitor combination, the future in eradicating multidrug resistance

A Duda-Madej, S Viscardi, E Topola - Antibiotics, 2023 - mdpi.com
Due to the fact that there is a steadily increasing trend in the area of antimicrobial resistance
in microorganisms, there is a need to look for new treatment alternatives. One of them is the …

Current understanding of potential linkages between biocide tolerance and antibiotic cross-resistance

K Coombs, C Rodriguez-Quijada, JO Clevenger… - Microorganisms, 2023 - mdpi.com
Antimicrobials (eg, antibiotics and biocides) are invaluable chemicals used to control
microbes in numerous contexts. Because of the simultaneous use of antibiotics and …

[HTML][HTML] Deciphering variable resistance to novel carbapenem-based β-lactamase inhibitor combinations in a multi-clonal outbreak caused by Klebsiella pneumoniae …

V Di Pilato, L Principe, L Andriani, N Aiezza… - Clinical Microbiology …, 2023 - Elsevier
Abstract Objectives Carbapenemase-producing Enterobacterales represent a major cause
of difficult-to-treat infections world-wide. Novel β-lactam/β-lactamase inhibitor combinations …

Treatment and diagnosis of severe KPC-producing Klebsiella pneumoniae infections: a perspective on what has changed over last decades

DR Giacobbe, V Di Pilato, I Karaiskos, T Giani… - Annals of …, 2023 - Taylor & Francis
Antimicrobial resistance is a global health threat. Among Gram-negative bacteria, resistance
to carbapenems, a class of β-lactam antibiotics, is usually a proxy for difficult-to-treat …

Functional features of KPC-109, a novel 270-loop KPC-3 mutant mediating resistance to avibactam-based β-lactamase inhibitor combinations and cefiderocol

V Di Pilato, G Codda, C Niccolai, E Willison… - International Journal of …, 2024 - Elsevier
Objectives To investigate a ceftazidime/avibactam (CZA)-resistant Klebsiella pneumoniae
(NE368), isolated from a patient exposed to CZA, expressing a novel K. pneumoniae …

A review of current antibiotic resistance and promising antibiotics with novel modes of action to combat antibiotic resistance

L Chen, S Kumar, H Wu - Archives of Microbiology, 2023 - Springer
The emergence and transmission of antibiotic resistance is a global public health crisis with
significant burden on healthcare systems, resulting in high mortality and economic costs. In …

Exploring avibactam and relebactam inhibition of Klebsiella pneumoniae carbapenemase D179N variant: role of the Ω loop-held deacylation water

TA Alsenani, SL Viviani, KM Papp-Wallace… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
ABSTRACT Klebsiella pneumoniae carbapenemase-2 (KPC-2) presents a clinical threat as
this β-lactamase confers resistance to carbapenems. Recent variants of KPC-2 in clinical …