Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Neuropsychiatric involvement of SLE includes a variety of symptoms that impact quality of
life and patient prognosis. There have been recent advances in improving the diagnosis of …

Cognitive impairment is a frequent manifestation of neuropsychiatric systemic lupus
erythematosus, present in up to 80% of patients and leading to a diminished quality of life. In …

Study design issues related to patient selection (non-NPSLE vs. NPSLE syndromes, SLE
disease activity, medications) are critical for biomarker development. Regional and network …

Patients with Systemic lupus erythematosus (SLE) experience various peripheral and
central nervous system manifestations including spatial memory impairment. A subset of …

For people with chronic autoimmune rheumatic diseases (AIRD), such as rheumatoid
arthritis (RA), systemic lupus erythematosus (SLE) or systemic sclerosis (SSc), normal …

Cognitive dysfunction (CD) is an insidious and underdiagnosed manifestation of systemic
lupus erythematosus (SLE) that has a considerable impact on quality of life, which can be …

NMDA receptors are ligand-gated ion channels that are found throughout the brain and are
required for both brain development and many higher order functions. A variety of human …

Neuropsychiatric manifestations of systemic lupus erythematosus (SLE) are common and
frequently associated with a substantial negative impact on health outcomes. The …

Cognitive impairment (CI) frequently occurs in patients with systemic lupus erythematosus
(SLE) and may result from neuroinflammation processes and neurovascular changes in the …