Alzheimer's disease (AD) constitutes the most prominent form of dementia among elderly
individuals worldwide. Disease modeling using murine transgenic mice was first initiated …

Background Brain age is a biomarker that predicts chronological age using neuroimaging
features. Deviations of this predicted age from chronological age is considered a sign of age …

Frontotemporal dementia (FTD) encompasses a spectrum of clinical syndromes
characterized by progressive executive, behavioural and language dysfunction. The various …

A limitation of conventional bulk-tissue proteome studies in amyotrophic lateral sclerosis
(ALS) is the confounding of motor neuron (MN) signals by admixed non-MN proteins. Here …

Proteinaceous aggregates are major hallmarks of several neurodegenerative diseases.
Aggregates of post-translationally modified transactive response (TAR)-DNA binding protein …

The human plasma proteome mirrors the physiological state of the cardiovascular system, a
fact that has been used to analyze plasma biomarkers in routine analysis for the diagnosis …

Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disorder,
caused by the degeneration of upper and lower motor neurons for which there is no truly …

Amyotrophic lateral sclerosis (ALS) is an adult-onset paralytic disease characterized by
progressive degeneration of upper and lower motor neurons in the motor cortex, brainstem …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are severely
debilitating and progressive neurodegenerative disorders. A distinctive pathological feature …

Frontotemporal dementia (FTD) is one of the most common neurodegenerative diseases,
encompassing a myriad of different, clinically distinct subtypes which all target the …