The role of epigenetic modifications in human cancers and the use of natural compounds as epidrugs: Mechanistic pathways and pharmacodynamic actions

A Bouyahya, H Mechchate, L Oumeslakht, I Zeouk… - Biomolecules, 2022 - mdpi.com
Cancer is a complex disease resulting from the genetic and epigenetic disruption of normal
cells. The mechanistic understanding of the pathways involved in tumor transformation has …

Preclinical activities of epigallocatechin gallate in signaling pathways in cancer

M Sharifi-Rad, R Pezzani, M Redaelli, M Zorzan… - Molecules, 2020 - mdpi.com
Epigallocatechin gallate (EGCG) is the main bioactive component of catechins
predominantly present in various types of tea. EGCG is well known for a wide spectrum of …

Toward heterogeneous information fusion: bipartite graph convolutional networks for in silico drug repurposing

Z Wang, M Zhou, C Arnold - Bioinformatics, 2020 - academic.oup.com
Motivation Mining drug–disease association and related interactions are essential for
developing in silico drug repurposing (DR) methods and understanding underlying …

Progress and promises of epigenetic drugs and epigenetic diets in cancer prevention and therapy: A clinical update

P Mondal, J Natesh, D Penta, SM Meeran - Seminars in Cancer Biology, 2022 - Elsevier
Epigenetic modifications are heritable yet reversible, essential for normal physiological
functions and biological development. Aberrant epigenetic modifications, including DNA …

The Role of EGCG in Breast Cancer Prevention and Therapy.

A Romano, F Martel - Mini reviews in medicinal chemistry, 2021 - ingentaconnect.com
Background: Breast cancer is the most frequent cancer in women. Green tea has been
studied for breast cancer chemopreventive and possibly chemotherapeutic effects due to its …

Current view on green tea catechins formulations, their interactions with selected drugs, and prospective applications for various health conditions

M Cerbin-Koczorowska, M Waszyk-Nowaczyk… - Applied Sciences, 2021 - mdpi.com
Green tea extract (GTE) is one of the most popular beverages globally, traditionally prepared
from Camelia sinensis leaves. Therefore, it is beneficial to define the impact of GTE and its …

Dynamic changes of DNA methylation induced by benzo (a) pyrene in cancer

H Wang, B Liu, H Chen, P Xu, H Xue, J Yuan - Genes and Environment, 2023 - Springer
Abstract Benzo (a) pyrene (BaP), the earliest and most significant carcinogen among
polycyclic aromatic hydrocarbons (PAHs), has been found in foods, tobacco smoke, and …

The potential role of Epigallocatechin-3-Gallate (EGCG) in breast cancer treatment

V Marín, V Burgos, R Pérez, DA Maria, P Pardi… - International Journal of …, 2023 - mdpi.com
Breast cancer is one of the most diagnosed cancers worldwide, with an incidence of 47.8%.
Its treatment includes surgery, radiotherapy, chemotherapy, and antibodies giving a mortality …

Epigenetic Activation of BRCA1 by Genistein In Vivo and Triple Negative Breast Cancer Cells Linked to Antagonism toward Aryl Hydrocarbon Receptor

MG Donovan, OI Selmin, TC Doetschman… - Nutrients, 2019 - mdpi.com
Triple negative breast cancers (TNBC) are the most aggressive and lethal breast cancers
(BC). The aryl hydrocarbon receptor (AHR) is often overexpressed in TNBC, and its …

Combination chemotherapy with selected polyphenols in preclinical and clinical studies—An update overview

C Jakobušić Brala, A Karković Marković, A Kugić… - Molecules, 2023 - mdpi.com
This review article describes studies published over the past five years on the combination
of polyphenols, which are the most studied in the field of anticancer effects (curcumin …