Proteins belong to the most complex colloidal system in terms of their physicochemical
properties, size and conformational-flexibility. This complexity contributes to their great …

The availability of whole-genome sequence data, made possible by significant advances in
DNA sequencing technology, led to the emergence of structural genomics projects in the …

Serial crystallography, at both synchrotron and X-ray free-electron laser light sources, is
becoming increasingly popular. However, the tools in the majority of crystallization …

Fragment-based drug discovery (FBDD) has become a mainstream technology for the
identification of chemical hit matter in drug discovery programs. To date, the food and drug …

Highlights•Review of fragment–protein crystallisation focusing on ligand introduction.•Hands-
on experience with crystallisation in a fragment-based project.•Donation of structure affinity …

Protein Crystallography or Macromolecular Crystallography (MX) started as a new discipline
of science with the pioneering work on the determination of the protein crystal structures by …

Protein crystallization was first discovered in the nineteenth century and has been studied
for nearly 200 years. Protein crystallization technology has recently been widely used in …

X-ray crystallography has long been a key method in solving the three-dimensional structure
of proteins. Structural information is essential for unraveling the molecular function of …

Structure-based drug design (SBDD) heavily relies on the production of high-resolution (<
2Å) three-dimensional (3D) structures of the drug target in the presence or absence of the …

Although protein crystallization is generally considered more art than science and remains
significantly trial-and-error, large-scale data sets hold the promise of providing general …