In theory, in vitro and in vivo models for human gliomas have great potential to not only
enhance our understanding of glioma biology, but also to facilitate the development of novel …

Abstract Isocitrate dehydrogenase 1 and 2 (IDH1/2) are key enzymes in cellular metabolism,
epigenetic regulation, redox states, and DNA repair. IDH1/2 mutations are causal in the …

Gliomas are the most common primary brain tumors in adults. They arise in the glial tissue
and primarily occur in the brain. Low‐grade tumors of World Health Organization (WHO) …

Heterozygous mutations in NADP‐dependent isocitrate dehydrogenases (IDH) define the
large majority of diffuse gliomas and are associated with hypermethylation of DNA and …

Abstract Isocitrate dehydrogenase 1 (IDH1) is mutated in various types of human cancer to
IDH1R132H, a structural alteration that leads to catalysis of α-ketoglutarate to the …

Glioblastoma multiforme (GBM), or grade IV astrocytoma, is the most common type of
primary brain tumor. It has a devastating prognosis with a 2-year-overall survival rate of only …

Epileptic seizures are frequent in patients with glioblastoma, and anticonvulsive treatment is
often necessary. While clinical guidelines recommend all approved anticonvulsants, so far it …

Introduction High-grade chondrosarcoma, high-grade glioma and intrahepatic
cholangiocarcinoma are aggressive types of cancer with a dismal outcome. This is due to …

Many patients with glioma harbor specific mutations in the isocitrate dehydrogenase gene
IDH1 that associate with a relatively better prognosis. IDH1-mutated tumors produce the …

Hotspot mutations in isocitrate dehydrogenase 1 (IDH1) initiate low-grade glioma and
secondary glioblastoma and induce a neomorphic activity that converts α-ketoglutarate (α …