Cancers are heterogeneous at the cell level, and the mechanisms leading to cancer
heterogeneity could be clonal evolution or cancer stem cells. Cancer stem cells are resistant …

The cancer stem cell (CSC) model proposes that tumor development and progression are
fueled and sustained by undifferentiated cancer cells, endowed with self-renewal and tumor …

Ovarian cancer spheroids constitute a metastatic niche for transcoelomic spread that also
engenders drug resistance. Spheroid-forming cells express active STAT3 signaling and …

Ovarian cancer (OC) is the fifth leading cause of cancer‐related death among women. The
high mortality rate is due to lack of early symptoms, late diagnosis, limited treatment options …

Overexpression of EZH2 in estrogen receptor negative (ER-) breast cancer promotes
metastasis. EZH2 has been mainly studied as the catalytic component of the Polycomb …

Accumulating evidence has shown that Signal Transducer and Activator of Transcription 3
(STAT3) is thought to be a promising target for cancer therapy as STAT3 is frequently …

Increased collagen deposition by breast cancer (BC)-associated mesenchymal
stem/multipotent stromal cells (MSC) promotes metastasis, but the mechanisms are …

The concept of a “cancer stem cell” has evolved over the past decades, and research on
cancer stem cell biology has entered into a stage of remarkable progress. Cancer stem cells …

The majority of women diagnosed with epithelial ovarian cancer eventually develop
recurrence, which rapidly evolves into chemoresistant disease. Persistence of ovarian …

The identity of cancer stem cells (CSCs) remains an enigma, with the question outstanding
of whether CSCs are fixed entities or plastic cell states in response to microenvironmental …