Neutrophils and monocytes belong to the first line of immune defence cells and are recruited
to sites of inflammation during infection or sterile injury. Both cells contain huge amounts of …

The S100 protein family consists of 24 members functionally distributed into three main
subgroups: those that only exert intracellular regulatory effects, those with intracellular and …

BACKGROUND: Atopic dermatitis (AD) is a common disease with an increasing prevalence.
The primary pathogenesis of the disease is still elusive, resulting in the lack of specific …

Zinc (II) ions are redox-inert in biology. Yet, their interaction with sulfur of cysteine in cellular
proteins can confer ligand-centered redox activity on zinc coordination sites, control protein …

To identify new components that regulate the inflammatory cascade during sepsis, we
characterized the functions of myeloid-related protein-8 (Mrp8, S100A8) and myeloid-related …

Abstract S100A8 and S100A9 are novel members of the group of damage–associated
molecular pattern molecules (DAMP) which are early amplifiers of innate immune responses …

Damage-associated molecular pattern (DAMP) molecules have been introduced as
important proinflammatory factors of innate immunity. One example known for many years to …

The S100 protein family is the largest subgroup within the superfamily of proteins carrying
the Ca2+-binding EF-hand motif. Despite their small molecular size and their conserved …

Transition metals are required cofactors for many proteins that are critical for life, and their
concentration within cells is carefully maintained to avoid both deficiency and toxicity. To …

Calprotectin (S100A8/A9), a heterodimer of the two calcium-binding proteins S100A8 and
S100A9, was originally discovered as immunogenic protein expressed and secreted by …