Exploring the evidence for epigenetic regulation of environmental influences on child health across generations

CV Breton, R Landon, LG Kahn, MB Enlow… - Communications …, 2021 - nature.com
Environmental exposures, psychosocial stressors and nutrition are all potentially important
influences that may impact health outcomes directly or via interactions with the genome or …

Early childhood wheezers: identifying asthma in later life

A Lasso-Pirot, S Delgado-Villalta… - Journal of asthma and …, 2015 - Taylor & Francis
Wheeze in young children is common, and asthma is the most common noncommunicable
disease in children. Prevalence studies of recurrent asthma-like symptoms in children under …

Mouse models of asthma

N Debeuf, E Haspeslagh, M van Helden… - Current protocols in …, 2016 - Wiley Online Library
Allergic asthma is a chronic inflammatory disease of the conducting airways characterized
by the presence of allergen‐specific IgE, Th2 cytokine production, eosinophilic airway …

A population-based prospective cohort study examining the influence of early-life respiratory tract infections on school-age lung function and asthma

ER van Meel, HT den Dekker, NJ Elbert, PW Jansen… - Thorax, 2018 - thorax.bmj.com
Background Early-life respiratory tract infections could affect airway obstruction and increase
asthma risk in later life. However, results from previous studies are inconsistent. Objective …

Promoter methylation of yes-associated protein (YAP1) gene in polycystic ovary syndrome

LL Jiang, JK Xie, JQ Cui, D Wei, BL Yin, YN Zhang… - Medicine, 2017 - journals.lww.com
Background: DNA methylation modification has been proved to influence the phenotype of
polycystic ovary syndrome (PCOS). Genome-wide association studies (GWAS) demonstrate …

Integrative genomics analysis of various omics data and networks identify risk genes and variants vulnerable to childhood-onset asthma

X Ma, P Wang, G Xu, F Yu, Y Ma - BMC Medical Genomics, 2020 - Springer
Background Childhood-onset asthma is highly affected by genetic components. In recent
years, many genome-wide association studies (GWAS) have reported a large group of …

The use of pharmacogenomics, epigenomics, and transcriptomics to improve childhood asthma management: where do we stand?

N Farzan, SJ Vijverberg, M Kabesch… - Pediatric …, 2018 - Wiley Online Library
Asthma is a complex multifactorial disease and it is the most common chronic disease in
children. There is a high variability in response to asthma treatment, even in patients with …

Novel genetic variants in long non-coding RNA MEG3 are associated with the risk of asthma

KL Chiu, WS Chang, CW Tsai, MC Mong, TC Hsia… - PeerJ, 2023 - peerj.com
Background Asthma is the most common chronic inflammatory airway disease worldwide.
Asthma is a complex disease whose exact etiologic mechanisms remain elusive; however, it …

[HTML][HTML] A retro-inverso modified peptide alleviated ovalbumin-induced asthma model by affecting glycerophospholipid and purine metabolism of immune cells

S Ma, K Yang, Z Li, L Li, Y Feng, X Wang… - Pulmonary …, 2023 - Elsevier
Allergic asthma is a heterogeneous disease involving a variety of inflammatory cells.
Immune imbalance or changes in the immune microenvironment are the essential causes …

5-HTP inhibits eosinophilia via intracellular endothelial 5-HTRs; SNPs in 5-HTRs associate with asthmatic lung function

MT Walker, JC Bloodworth, TS Kountz… - Frontiers in …, 2024 - frontiersin.org
Background Previous research showed that 5-hydroxytryptophan (5HTP), a metabolic
precursor of serotonin, reduces allergic lung inflammation by inhibiting eosinophil migration …