Recent advances in efficiency and ease of implementation have rekindled interest in ion
mobility spectrometry, a technique that separates gas phase ions by their size and shape …

Ion mobility spectrometry is an analytical technique known for more than 100 years, which
entails separating ions in the gas phase based on their size, shape, and charge. While ion …

Data-independent acquisition modes isolate and concurrently fragment populations of
different precursors by cycling through segments of a predefined precursor m/z range …

The size and shape of peptide ions in the gas phase are an under-explored dimension for
mass spectrometry-based proteomics. To investigate the nature and utility of the peptide …

A benchmark comparison between two ion mobility and collision cross-section (CCS)
calculators, MOBCAL and IMoS, is presented here as a standard to test the efficiency and …

Mass spectrometry-based profiling of the phosphoproteome is a powerful method of
identifying phosphorylation events at a systems level. Most phosphoproteomics studies have …

Four-dimensional (4D) data-independent acquisition (DIA)-based proteomics is a promising
technology. However, its full performance is restricted by the time-consuming building and …

Post-translational modifications (PTMs) are ubiquitous and key to regulating protein function.
Understanding the dynamics of individual PTMs and their biological roles requires robust …

Mass spectrometry is the premier tool for identifying and quantifying protein phosphorylation
on a global scale. Analysis of phosphopeptides requires enrichment, and even after the …

Native top-down mass spectrometry (MS) and ion mobility spectrometry (IMS) were applied
to characterize the interaction of a molecular tweezer assembly modulator, CLR01, with tau …