T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …

Adoptive cell therapy using chimeric antigen receptor (CAR) technology is one of the most
advanced engineering platforms for cancer immunotherapy. CAR-T cells have shown …

Background Chimeric antigen receptor macrophage (CAR-M) therapy is a novel cancer
immunotherapy approach that integrates CAR structure and macrophage functions. CAR-M …

The incidence and mortality of cancer are the major health issue worldwide. Apart from the
treatments developed to date, the unsatisfactory therapeutic effects of cancers have not …

Remarkable improvement relative to traditional approaches in the treatment of
hematological malignancies by chimeric antigen receptor (CAR) T-cell therapy has …

Genetic modification of cells using viral vectors has shown huge therapeutic benefit in
multiple diseases. However, inefficient transduction contributes to the high cost of these …

Simple Summary This is a comprehensive overview of the approved chimeric antigen
receptor T-cell products (CAR T-cells), their specific indications, treatment-related side …