Modeling cardiomyocyte signaling and metabolism predicts genotype-to-phenotype mechanisms in hypertrophic cardiomyopathy

A Khalilimeybodi, JJ Saucerman… - Computers in Biology and …, 2024 - Elsevier
Familial hypertrophic cardiomyopathy (HCM) is a significant precursor of heart failure and
sudden cardiac death, primarily caused by mutations in sarcomeric and structural proteins …

Network model of skeletal muscle cell signalling predicts differential responses to endurance and resistance exercise training

A Fowler, KR Knaus, S Khuu… - Experimental …, 2024 - Wiley Online Library
Exercise‐induced muscle adaptations vary based on exercise modality and intensity. We
constructed a signalling network model from 87 published studies of human or rodent …