The complex interplay between redox dysregulation and mTOR signaling pathway in cancer: A rationale for cancer treatment

C Glorieux, C Enríquez, PB Calderon - Biochemical Pharmacology, 2024 - Elsevier
The mechanistic target of rapamycin (mTOR) is a highly conserved serine/threonine kinase
that plays a critical role in regulating cellular processes such as growth, proliferation, and …

The Long Journey towards Personalized Targeted Therapy in Poorly Differentiated Thyroid Carcinoma (PDTC): A Case Report and Systematic Review

O Violetis, P Konstantakou, A Spyroglou… - Journal of Personalized …, 2024 - mdpi.com
Background: Poorly differentiated thyroid carcinoma (PDTC) has an intermediate prognosis
between indolent well-differentiated thyroid carcinoma (TC) and anaplastic carcinoma …

PTEN inhibits epithelial mesenchymal transition of thyroid cancer cells by regulating the Wnt/β-Catenin signaling pathway

L Wei, Q Liang, C Zhou, R Liu, Y Liu - Discover Oncology, 2024 - Springer
Objective The global incidence of thyroid cancer (THCA) has significantly risen in recent
years. This study aims to investigate the role and mechanisms of PTEN in epithelial …

[HTML][HTML] A Paradoxical AKT: Exploring the Promise and Challenges of PI3K/AKT/mTOR Targeted Therapies

GL Parkman, SL Holmen - Journal of cancer immunology, 2024 - pmc.ncbi.nlm.nih.gov
A Paradoxical AKT: Exploring the Promise and Challenges of PI3K/AKT/mTOR Targeted
Therapies - PMC Skip to main content Here's how you know Official websites use .gov A .gov …