Serotonin, tryptophan metabolism and the brain-gut-microbiome axis

SM O'Mahony, G Clarke, YE Borre, TG Dinan… - Behavioural brain …, 2015 - Elsevier
The brain-gut axis is a bidirectional communication system between the central nervous
system and the gastrointestinal tract. Serotonin functions as a key neurotransmitter at both …

[HTML][HTML] Discriminative and affective touch: sensing and feeling

F McGlone, J Wessberg, H Olausson - Neuron, 2014 - cell.com
The multimodal properties of the human somatosensory system continue to be unravelled.
There is mounting evidence that one of these submodalities—touch—has another …

[HTML][HTML] Directed evolution of a selective and sensitive serotonin sensor via machine learning

EK Unger, JP Keller, M Altermatt, R Liang, A Matsui… - Cell, 2020 - cell.com
Serotonin plays a central role in cognition and is the target of most pharmaceuticals for
psychiatric disorders. Existing drugs have limited efficacy; creation of improved versions will …

Signalling cognition: the gut microbiota and hypothalamic-pituitary-adrenal axis

JA Rusch, BT Layden, LR Dugas - Frontiers in endocrinology, 2023 - frontiersin.org
Cognitive function in humans depends on the complex and interplay between multiple body
systems, including the hypothalamic-pituitary-adrenal (HPA) axis. The gut microbiota, which …

Resilience and the brain: a key role for regulatory circuits linked to social stress and support

NE Holz, H Tost, A Meyer-Lindenberg - Molecular psychiatry, 2020 - nature.com
Given the high prevalence and burden of mental disorders, fostering the understanding of
protective factors is an urgent issue for translational medicine in psychiatry. The concept of …

Neural circuits regulating prosocial behaviors

JJ Walsh, DJ Christoffel, RC Malenka - Neuropsychopharmacology, 2023 - nature.com
Positive, prosocial interactions are essential for survival, development, and well-being.
These intricate and complex behaviors are mediated by an amalgamation of neural circuit …

Probiotic modulation of the microbiota-gut-brain axis and behaviour in zebrafish

L Borrelli, S Aceto, C Agnisola, S De Paolo… - Scientific reports, 2016 - nature.com
The gut microbiota plays a crucial role in the bi-directional gut–brain axis, a communication
that integrates the gut and central nervous system (CNS) activities. Animal studies reveal …

Physical activity promotes brain development through serotonin during early childhood

JQ Jing, SJ Jia, CJ Yang - Neuroscience, 2024 - Elsevier
Early childhood serves as a critical period for neural development and skill acquisition when
children are extremely susceptible to the external environment and experience. As a crucial …

The human neuropsychiatric risk gene Drd2 is necessary for social functioning across evolutionary distant species

KGO Ike, SJC Lamers, S Kaim, SF de Boer… - Molecular …, 2024 - nature.com
The Drd2 gene, encoding the dopamine D 2 receptor (D2R), was recently indicated as a
potential target in the etiology of lowered sociability (ie, social withdrawal), a symptom of …

The neurobiology of human aggressive behavior: neuroimaging, genetic, and neurochemical aspects

FA Cupaioli, FA Zucca, C Caporale, KP Lesch… - Progress in neuro …, 2021 - Elsevier
In modern societies, there is a strive to improve the quality of life related to risk of crimes
which inevitably requires a better understanding of brain determinants and mediators of …