Simplifying switch to second-line antiretroviral therapy in sub Saharan Africa: predicted effect of using a single viral load to define efavirenz-based first-line failure

A Shroufi, G Van Cutsem, V Cambiano… - Aids, 2019 - journals.lww.com
Background: Many individuals failing first-line antiretroviral therapy (ART) in sub-Saharan
Africa never initiate second-line ART or do so after significant delay. For people on ART with …

Predictors of treatment failure, time to switch and reasons for switching to second line antiretroviral therapy in HIV infected children receiving first line anti-retroviral …

GS Haile, AB Berha - BMC pediatrics, 2019 - Springer
Background Treatment failure and delay in switching to second line regimen are major
concerns in the treatment of HIV infected children in a resource limited setting. The aim of …

[HTML][HTML] HIV-1 drug resistance in adults and adolescents on protease inhibitor-based antiretroviral therapy in KwaZulu-Natal Province, South Africa

B Chimukangara, RJ Lessells, B Sartorius… - Journal of Global …, 2022 - Elsevier
Objectives In low–middle-income countries, increasing levels of HIV drug resistance
(HIVDR) on second-line protease inhibitor (PI)-based regimens are a cause for concern …

Delays in repeat HIV viral load testing for those with elevated viral loads: a national perspective from South Africa

MP Fox, AT Brennan, C Nattey… - Journal of the …, 2020 - Wiley Online Library
Abstract Introduction In South Africa, HIV patients with an elevated viral load (VL) should
receive repeat VL testing after adherence counselling. We set out to use a national HIV …

Provision of HIV viral load testing services in Zimbabwe: Secondary data analyses using data from health facilities using the electronic Patient Monitoring System

T Apollo, KC Takarinda, A Phillips, C Ndhlovu… - PloS one, 2021 - journals.plos.org
Introduction Routine viral load (VL) testing among persons living with Human
Immunodeficiency Virus (PLHIV) enables earlier detection of sub-optimal antiretroviral …

Determinants of virologic failure among adults on second line antiretroviral therapy in Wollo, Amhara Regional State, Northeast Ethiopia

A Seid, N Cherie, K Ahmed - HIV/AIDS-Research and Palliative …, 2020 - Taylor & Francis
Background Treatment failure among the population on second line antiretroviral therapy is
a major public health threat. In Ethiopia there has been limited research done on second …

Clinical predictor score to identify patients at risk of poor viral load suppression at six months on antiretroviral therapy: results from a prospective cohort study in …

MAS Mbengue, C Chasela, D Onoya… - Clinical …, 2019 - Taylor & Francis
Purpose: As countries work toward 90: 90: 90 targets, early identification of patients with
inadequate response to antiretroviral therapy (ART) is critical for achieving optimal HIV …

Predictors of virological failure among people living with HIV receiving first line antiretroviral treatment in Myanmar: retrospective cohort analysis

A Mesic, A Spina, HT Mar, P Thit, T Decroo… - AIDS Research and …, 2021 - Springer
Background Progress toward the global target for 95% virological suppression among those
on antiretroviral treatment (ART) is still suboptimal. We describe the viral load (VL) cascade …

Trends and correlates in HIV viral load monitoring and viral suppression among adolescents and young adults in Dar es Salaam, Tanzania

J Rugemalila, PP Kunambi, M Amour… - Tropical Medicine & …, 2024 - Wiley Online Library
Background Adolescents and young adults (AYA) living with HIV have been shown to have
lower rates of viral load testing and viral suppression as compared to older adults. We …

Impact of Viral Load Monitoring on Retention and Viral Suppression: A Regression Discontinuity Analysis of South Africa's National Laboratory Cohort

AF Harlow, J Bor, AT Brennan… - American Journal of …, 2020 - academic.oup.com
South African guidelines recommend repeat viral load testing within 6 months when human
immunodeficiency virus (HIV) viral loads exceed 1,000 copies/mL. We assessed whether …