A not-so-ancient grease history: click chemistry and protein lipid modifications

KF Suazo, KY Park, MD Distefano - Chemical reviews, 2021 - ACS Publications
Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …

[HTML][HTML] Regulation of antiviral immune response by African swine fever virus (ASFV)

X Zheng, S Nie, WH Feng - Virologica Sinica, 2022 - Elsevier
African swine fever (ASF) is a highly contagious and acute hemorrhagic viral disease with a
high mortality approaching 100% in domestic pigs. ASF is an endemic in countries in sub …

[HTML][HTML] Regulation of protein prenylation

D Jung, HS Bachmann - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Prenyltransferases (PTases) are known to play a role in embryonic development, normal
tissue homeostasis and cancer by posttranslationally modifying proteins involved in these …

Association between cardiometabolic risk factors and COVID-19 susceptibility, severity and mortality: a review

Y Sharifi, M Payab, E Mohammadi-Vajari… - Journal of Diabetes & …, 2021 - Springer
The novel coronavirus, which began spreading from China Wuhan and gradually spreaded
to most countries, led to the announcement by the World Health Organization on March 11 …

Cholesterol-modifying drugs in COVID-19

NM Schmidt, PAC Wing, JA McKeating… - Oxford open …, 2020 - academic.oup.com
Infection with severe acute respiratory syndrom coronavirus 2 (SARS-CoV-2) is more likely
to lead to poor outcomes in the elderly and those with cardiovascular disease, obesity or …

The L83L ORF of African swine fever virus strain Georgia encodes for a non-essential gene that interacts with the host protein IL-1β

MV Borca, V O'Donnell, LG Holinka, E Ramírez-Medina… - Virus research, 2018 - Elsevier
African swine fever virus (ASFV) causes a contagious and frequently lethal disease of pigs
causing significant economic consequences to the swine industry. The ASFV genome …

New approaches to the prevention and treatment of viral diseases

AV Pronin, AN Narovlyansky, AV Sanin - Archivum Immunologiae et …, 2021 - Springer
The review discusses a new approach to the prevention and treatment of viral infections
based on the use of pine needles polyprenyl phosphate (PPP) and associated with the …

Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages

MA Munoz, EK Fletcher, OP Skinner, J Jurczyluk… - Elife, 2021 - elifesciences.org
Bisphosphonates drugs target the skeleton and are used globally for the treatment of
common bone disorders. Nitrogen-containing bisphosphonates act by inhibiting the …

Statin-mediated disruption of Rho GTPase prenylation and activity inhibits respiratory syncytial virus infection

M Malhi, MJ Norris, W Duan, TJ Moraes… - Communications …, 2021 - nature.com
Respiratory syncytial virus (RSV) is a leading cause of severe respiratory tract infections in
children. To uncover new antiviral therapies, we developed a live cell-based high content …

Potential Effect of Statins on Mycobacterium tuberculosis Infection

PDC Guerra-De-Blas… - Journal of …, 2018 - Wiley Online Library
Tuberculosis is one of the 10 leading causes of death in the world. The current treatment is
based on a combination of antimicrobials administered for six months. It is essential to find …