Deoxyribonucleoside kinases phosphorylate deoxyribonucleosides, a crucial reaction in
biosynthesis of DNA precursors through the salvage pathway. Their medical interest stems …

Approximately 5% of the world's human population have an increased risk for developing
liver cancer and cirrhosis as a direct consequence of chronic infection with the hepatitis B …

US7608597B2 - Methods and compositions for treating hepatitis C virus - Google Patents
US7608597B2 - Methods and compositions for treating hepatitis C virus - Google Patents …

ABSTRACT A unique series of simple “unnatural” nucleosides has been discovered to
inhibit hepatitis B virus (HBV) replication. Through structure-activity analysis it was found that …

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Flaviviridae infection that includes the administration of a 2'-branched nucleoside, or a
pharmaceutically acceptable prodrug and/or salt thereof, to a human in need of therapy in …

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Three simple, related nucleosides, β-L-2′-deoxycytidine (LdC), β-Lthymidine (LdT), and β-
L-2′-deoxyadenosine (LdA), have been discovered to be potent, specific and selective …

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Maintenance of the information embedded in the genomic DNA sequence is essential for
life. DNA polymerases play pivotal roles in the complex processes that maintain genetic …