The cytoskeleton and its components—actin, microtubules and intermediate filaments—
have been studied for decades, and multiple roles of the individual cytoskeletal …

Recent evidence suggests that glycogen synthase kinase 3 (GSK3) proteins and their
upstream and downstream regulators have key roles in many fundamental processes during …

Migration is a polarized cellular process that opposes a protrusive front edge to a retracting
trailing edge. From the front to the rear, actin-mediated forces sequentially promote cell …

Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved
serine/threonine protein kinase encoded in mammals by two genes that generate two …

Microtubules are filamentous polymers essential for cell viability. Microtubule plus-end
tracking proteins (+ TIPs) associate with growing microtubule plus ends and control …

Nearly 100 proteins are proposed to be substrates for GSK3, suggesting that this enzyme is
a fundamental regulator of almost every process in the cell, in every tissue in the body …

This article is part of a Minifocus on microtubule dynamics. For further reading, please see
related articles:'Kinesins at a glance'by Sharyn A. Endow et al.,(J. Cell Sci. 123, pp. 3420 …

Turnover of integrin-based focal adhesions (FAs) with the extracellular matrix (ECM) is
essential for coordinated cell movement. In collectively migrating human keratinocytes, FAs …

The molecular mechanisms by which microtubule-associated proteins (MAPs) regulate the
dynamic properties of microtubules (MTs) are still poorly understood. We review recent …

Directional cell migration requires force generation that relies on the coordinated
remodeling of interactions with the extracellular matrix (ECM), which is mediated by integrin …