Drug molecules transformed into nanoparticles or endowed with nanostructures with or
without the aid of carrier materials are referred to as “nanomedicines” and can overcome …

Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

The poor oral bioavailability arising from poor aqueous solubility should make drug research
and development more difficult. Various approaches have been developed with a focus on …

As nano-sizing is becoming a more common approach for pharmaceutical product
development, researchers are taking advantage of the unique inherent properties of …

Rapid advancement in drug discovery process is leading to a number of potential new drug
candidates having excellent drug efficacy but limited aqueous solubility. By virtue of the …

A significant percentage of active pharmaceutical ingredients identified through discovery
screening programs is poorly soluble in water. These molecules are often difficult to …

Nanosizing is one of the most important drug delivery platform approaches for the
commercial development of poorly soluble drug molecules. The research efforts of many …

Poor aqueous solubility represents a major hurdle in achieving adequate oral bioavailability
for a large percentage of drug compounds in drug development nowadays. Nanosizing …

During the last 10–15 years, the formulation of drugs as nanocrystals has rapidly evolved
into a mature drug delivery strategy, with currently five products on the market. The major …

Objectives Wet milling is a common technique to produce drug nanocrystals. Stability of the
nanocrystals is a critical question, and different kinds of stabilizers, eg polymers, celluloses …