Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly
globally. Emerging evidence has demonstrated microglia-driven neuroinflammation as a key …

Occupational exposure to hexavalent chromium (Cr (VI)) can cause cytotoxicity and
carcinogenicity. In this study, we established a liver injury model in rats via intraperitoneal …

Background. Osteoarthritis (OA) is a progressive illness that destroys cartilage. Oxidative
stress is a major contributor of OA, while endoplasmic reticulum (ER) stress is the key …

Spinal cord injury (SCI) is a devastating condition with few treatment options. Metformin, a
classical antidiabetic and antioxidant, has extended its application to experimental SCI …

Currently, there is increasing attention on the regulatory effects of cannabidiol (CBD) on the
inflammatory response and the immune system. However, the mechanisms have not yet …

Chlorpyrifos (CPF) is widely used in agriculture, plants, and buildings to kill pests and
worms. Excessive environmental residues of CPF will result in soil and ecological …

Echinacoside (ECH), the major active constituent of Cistanche deserticola, was found to
exert neuroprotection through neurotrophic and anti-inflammatory functions in Parkinson's …

Infected osteolysis as a common secondary osteoporosis is associated with excessive
osteoclastogenesis and bone resorption. The inhibition of osteoclastogenesis and bone …

Osteoarthritis (OA) is a common degenerative disease with few treatments. In traditional
Chinese medicine (TCM), Radix Angelicae biseratae (RAB) is commonly used to treat OA …

Cervical spondylotic myelopathy (CSM) refers to a chronic injury of the cervical cord caused
by cervical intervertebral disc degeneration. Endoplasmic reticulum (ER) homeostasis is …