Background: It is unclear whether more timely cancer diagnosis brings favourable outcomes,
with much of the previous evidence, in some cancers, being equivocal. We set out to …

Pediatric central nervous system (CNS) tumors are the second most common childhood
malignancy and the most common solid tumor in children. The incidence rate of childhood …

Diabetes insipidus is a disorder characterized by excretion of large amounts of hypotonic
urine. Four entities have to be differentiated: central diabetes insipidus resulting from a …

Primary CNS germ cell tumors (GCTs) are rare neoplasms predominantly observed in the
pediatric and young adult populations. In line with the hypothesis that the primordial germ …

Importance—Primary central nervous system (CNS) germ cell tumors (GCT) are a
heterogeneous group of tumors that are still poorly understood. In North America, GCTs …

Central diabetes insipidus (CDI) is a complex disorder in which large volumes of dilute urine
are excreted due to arginine-vasopressin deficiency, and it is caused by a variety of …

Context: Central diabetes insipidus (CDI) is considered idiopathic in 20% to 50% of affected
subjects. Objective: The purpose of this study was to determine whether a systematic …

Background Pituitary stalk thickening (PST) is a rare abnormality in the pediatric population.
Its etiology is heterogeneous. The aim of the study was to identify important clinical …

Unexplained or idiopathic pituitary stalk thickening or central diabetes insipidus not only
harbours rare occult malignancies in 40% of cases but can also reflect benign congenital …

CNS germinomas have an excellent prognosis with radiation therapy alone. However, in
children, volume and dose of CNS radiation are associated with neurocognitive and …