The tumor cell changes itself and its microenvironment to adapt to different situations,
including action of drugs and other agents targeting tumor control. Therefore, metabolism …

Abstract Therapy-Induced Senescence (TIS) is an established response to anticancer
therapy in a variety of cancer models. Ample evidence has characterized the triggers …

Anticancer therapy screening in vitro identifies additional treatments and improves clinical
outcomes. Systematically, although most tested cells respond to cues with apoptosis, an …

Although cellular senescence is believed to have a tumor suppressor function, senescent
cells have been shown to increase the potential for growth of adjacent cancer cells in animal …

The induction of senescence-like growth arrest has emerged as a putative contributor to the
anticancer effects of chemotherapeutic agents. Clinical trials are underway to evaluate the …

More than 30,000 people develop pancreatic adeno-carcinoma each year in the United
States, and almost all are expected to die from the disease. 1 The 5-year survival rate is 5 …

Cellular senescence, an irreversible cell-cycle arrest, reflects a safeguard program that limits
the proliferative capacity of the cell exposed to endogenous or exogenous stress signals. A …

Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis. In …

H2O2 has been the most commonly used inducer for stress-induced premature senescence
(SIPS), which shares features of replicative senescence. However, there is still uncertainty …

Biological signals need to be robust and filter small fluctuations yet maintain sensitivity to
signals across a wide range of magnitudes. Here, we studied how fluctuations in DNA …