Maleimide chemistry stands out in the bioconjugation toolbox by virtue of its synthetic
accessibility, excellent reactivity, and practicability. The second‐generation of clinically …

Oxidatively induced DNA damage is caused in living organisms by endogenous and
exogenous reactive species. DNA lesions resulting from this type of damage are mutagenic …

5-Methylene pyrrolones (5MPs) are highly thiol-specific and tracelessly removable
bioconjugation tools. 5MPs are readily prepared from primary amines in one step. 5MPs …

In situ generation of 5-formylcytosine (5fC) in nucleosome core particles (NCPs) reveals that
5fC leads to essential DNA–protein cross-links (DPCs). Mechanistic studies using chemical …

Abasic lesions are a family of DNA modifications that lack Watson–Crick bases. The parent
member of this family, the apurinic/apyrimidinic lesion (AP), occurs as an intermediate …

A highly efficient and general singlet‐oxygen‐initiated one‐pot transformation of readily
accessible furans into 5‐hydroxy‐1H‐pyrrol‐2 (5H)‐ones has been developed. The …

Monofunctional alkylating agents preferentially react at the N7 position of 2′-
deoxyguanosine in duplex DNA. Methylated DNA, such as that produced by methyl …

Oxo-7, 8-dihydro-2′-deoxyguanosine (8-oxodGuo) is a biomarker of oxidative DNA
damage and can be repaired by hOGG1 and APE1 via the base excision repair (BER) …

Conspectus DNA is damaged by various endogenous and exogenous sources, leading to a
diverse group of reactive intermediates that yield a complex mixture of products. The initially …

When designing prodrugs, choosing an appropriate linker is the key to achieving efficient,
controlled drug delivery. Herein, we report the use of a photocaged C4′-oxidized abasic …