The histone variant H2A. Z is involved in several processes such as transcriptional control,
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …

H2A. Z is a histone variant that provides specific structural and docking-side properties to the
nucleosome, resulting in diverse and specialised molecular and cellular functions. In this …

It is currently assumed that 3D chromosomal organization plays a central role in
transcriptional control. However, depletion of cohesin and CTCF affects the steady-state …

Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

Despite the well-established role of nuclear organization in the regulation of gene
expression, little is known about the reverse: how transcription shapes the spatial …

Summary The developmental disorder Floating-Harbor syndrome (FHS) is caused by
heterozygous truncating mutations in SRCAP, a gene encoding a chromatin remodeler …

The H2A. Z histone variant plays major roles in the control of gene expression. In human,
H2A. Z is encoded by two genes expressing two isoforms, H2A. Z. 1 and H2A. Z. 2 differing …

The nucleosome remodeling and deacetylase (NuRD) complex is essential for metazoan
development but has been refractory to biochemical analysis. We present an integrated …

Specialized chromatin-binding proteins are required for DNA-based processes during
development. We recently established PWWP2A as a direct histone variant H2A. Z interactor …

Abstract H2A. Z is a H2A‐type histone variant essential for many aspects of cell biology,
ranging from gene expression to genome stability. From deuterostomes, H2A. Z evolved into …