Bacteria possess complex and varying cell walls with many surface exposed proteins.
Sortases are responsible for the covalent attachment of specific proteins to the …

As a common intracellular facultative anaerobic Gram-positive bacterium, Listeria
monocytogenes (L. monocytogenes) exhibits strong resistance to extreme environments …

Sortase enzymes are vitally important for the virulence of gram‐positive bacteria as they play
a key role in the attachment of surface proteins to the cell wall. These enzymes recognize a …

Sortases are cysteine transpeptidases that assemble surface proteins and pili in their cell
envelope. Encoded by all Gram-positive bacteria, few Gram-negative bacteria and archaea …

Transpeptidation of surface proteins catalyzed by the transpeptidase sortase plays a critical
role in the infection process of Gram-positive pathogen, and probing sortase activity and …

The sortase A enzyme, which catalyzes the peptidoglycan cell wall anchoring reaction of
LPXTG surface proteins, has been proposed to be a universal target for therapeutic agents …

A unique feature of the class-C-type sortases, enzymes essential for Gram-positive pilus
biogenesis, is the presence of a flexible “lid” anchored in the active site. However, the …

Listeria monocytogenes (LM) is a classical model intracellular pathogen and the leading
cause of listeriosis, which has long been a global public health issue. The successful …

Gram-positive pathogens, such as Streptococcus pyogenes and Staphylococcus aureus, are
etiological agents of a large array of human diseases. Unfortunately, our ability to treat these …

Multi-drug resistance in Gram-positive bacteria is a growing and unwavering challenge for
twenty-first century medicine. The enzyme sortase, identified just around the turn of the …