Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
MJ Bissell, WC Hines - Nature medicine, 2011 - nature.com
Tumors are like new organs and are made of multiple cell types and components. The tumor
competes with the normal microenvironment to overcome antitumorigenic pressures. Before …
competes with the normal microenvironment to overcome antitumorigenic pressures. Before …
Warburg Meets Autophagy: Cancer-Associated Fibroblasts Accelerate Tumor Growth and Metastasis via Oxidative Stress, Mitophagy, and Aerobic Glycolysis
S Pavlides, I Vera, R Gandara, S Sneddon… - Antioxidants & redox …, 2012 - liebertpub.com
Significance: Here, we review certain recent advances in oxidative stress and tumor
metabolism, which are related to understanding the contributions of the microenvironment in …
metabolism, which are related to understanding the contributions of the microenvironment in …
[HTML][HTML] Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis
Mechanotransduction is a key determinant of tissue homeostasis and tumor progression. It is
driven by intercellular adhesions, cell contractility, and forces generated within the …
driven by intercellular adhesions, cell contractility, and forces generated within the …
[HTML][HTML] Role of cholesterol in the development and progression of breast cancer
G Llaverias, C Danilo, I Mercier, K Daumer… - The American journal of …, 2011 - Elsevier
Diet and obesity are important risk factors for cancer development. Many studies have
suggested an important role for several dietary nutrients in the progression and …
suggested an important role for several dietary nutrients in the progression and …
Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms
F Sotgia, UE Martinez-Outschoorn… - Annual Review of …, 2012 - annualreviews.org
Caveolins are a family of membrane-bound scaffolding proteins that compartmentalize and
negatively regulate signal transduction. Recent studies have implicated a loss of caveolin-1 …
negatively regulate signal transduction. Recent studies have implicated a loss of caveolin-1 …
An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers
Previously, we showed that caveolin-1 (Cav-1) expression is down-regulated in human
breast cancer-associated fibroblasts. However, it remains unknown whether loss of Cav-1 …
breast cancer-associated fibroblasts. However, it remains unknown whether loss of Cav-1 …
The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts
G Bonuccelli, D Whitaker-Menezes, R Castello-Cros… - Cell cycle, 2010 - Taylor & Francis
We and others have previously identified a loss of stromal caveolin-1 (Cav-1) in cancer-
associated fibroblasts (CAFs) as a powerful single independent predictor of breast cancer …
associated fibroblasts (CAFs) as a powerful single independent predictor of breast cancer …
Role of Caveolin‐1 in diabetes and its complications
It is estimated that in 2017 there were 451 million people with diabetes worldwide. These
figures are expected to increase to 693 million by 2045; thus, innovative preventative …
figures are expected to increase to 693 million by 2045; thus, innovative preventative …
Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention?
F Sotgia, UE Martinez-Outschoorn, MP Lisanti - BMC medicine, 2011 - Springer
The functional role of oxidative stress in cancer pathogenesis has long been a hotly debated
topic. A study published this month in BMC Cancer by Goh et al., directly addresses this …
topic. A study published this month in BMC Cancer by Goh et al., directly addresses this …
Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development
C Danilo, JL Gutierrez-Pajares, MA Mainieri… - Breast Cancer …, 2013 - Springer
Introduction Previous studies have identified cholesterol as an important regulator of breast
cancer development. High-density lipoprotein (HDL) and its cellular receptor, the scavenger …
cancer development. High-density lipoprotein (HDL) and its cellular receptor, the scavenger …