The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …

This theoretical article revives a classical bridging construct, canalization, to describe a new
model of a general factor of psychopathology. To achieve this, we have distinguished …

Fear and anxiety play a central role in mammalian life, and there is considerable interest in
clarifying their nature, identifying their biological underpinnings, and determining their …

Genome-wide association studies (GWAS) provide biological insights into disease onset
and progression and have potential to produce clinically useful biomarkers. A growing body …

Threat-anticipatory defensive responses have evolved to promote survival in a dynamic
world. While inherently adaptive, aberrant expression of defensive responses to potential …

Method As examples of the new approaches that have emerged, here we introduce the
Hierarchical Taxonomy of Psychopathology (HiTOP), the Research Domain Criteria (RDoC) …

Background An ongoing positive revolution advocates a new approach to the individual
differences in human emotions, cognitions, and behavior that cause distress and impair …

Alternatives to traditional categorical diagnoses have been proposed to improve the validity
and utility of psychiatric nosology. This paper continues the companion review of an …

Abstract The Hierarchical Taxonomy of Psychopathology (HiTOP) is a dimensional
framework for psychopathology advanced by a consortium of nosologists. In the HiTOP …

Background Semi-structured diagnostic interviews and symptom checklists present similar
internal reliability. We aim to investigate whether they differ in predicting poor life outcomes …