RNA G-quadruplexes in biology: principles and molecular mechanisms
Abstract G-quadruplexes (G4s) are extremely stable DNA or RNA secondary structures
formed by sequences rich in guanine. These structures are implicated in many essential …
formed by sequences rich in guanine. These structures are implicated in many essential …
[HTML][HTML] G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome
G-rich sequences in DNA and RNA have a propensity to fold into stable secondary
structures termed G-quadruplexes. G-quadruplex forming sequences are widespread …
structures termed G-quadruplexes. G-quadruplex forming sequences are widespread …
Properties and biological impact of RNA G-quadruplexes: from order to turmoil and back
P Kharel, G Becker, V Tsvetkov… - Nucleic acids research, 2020 - academic.oup.com
Abstract Guanine-quadruplexes (G4s) are non-canonical four-stranded structures that can
be formed in guanine (G) rich nucleic acid sequences. A great number of G-rich sequences …
be formed in guanine (G) rich nucleic acid sequences. A great number of G-rich sequences …
Detection of genomic G-quadruplexes in living cells using a small artificial protein
Abstract G-quadruplex (G4) structures formed by guanine-rich nucleic acids are implicated
in essential physiological and pathological processes and serve as important drug targets …
in essential physiological and pathological processes and serve as important drug targets …
G-Quadruplex: a regulator of gene expression and its chemical targeting
Summary G-quadruplex (G4) is an important type of nucleic acid secondary structure. An
abundance of potential G4-forming sites have been shown to exist in genomes, leading to …
abundance of potential G4-forming sites have been shown to exist in genomes, leading to …
Genome-wide analysis of DNA G-quadruplex motifs across 37 species provides insights into G4 evolution
F Wu, K Niu, Y Cui, C Li, M Lyu, Y Ren, Y Chen… - Communications …, 2021 - nature.com
Abstract G-quadruplex (G4) structures have been predicted in the genomes of many
organisms and proven to play regulatory roles in diverse cellular activities. However, there is …
organisms and proven to play regulatory roles in diverse cellular activities. However, there is …
RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation
E Dardenne, MP Espinoza, L Fattet, S Germann… - Cell reports, 2014 - cell.com
The RNA helicases DDX5 and DDX17 are members of a large family of highly conserved
proteins that are involved in gene-expression regulation; however, their in vivo targets and …
proteins that are involved in gene-expression regulation; however, their in vivo targets and …
Structure and function of multimeric G-quadruplexes
S Kolesnikova, EA Curtis - Molecules, 2019 - mdpi.com
G-quadruplexes are noncanonical nucleic acid structures formed from stacked guanine
tetrads. They are frequently used as building blocks and functional elements in fields such …
tetrads. They are frequently used as building blocks and functional elements in fields such …
Structure, properties, and biological relevance of the DNA and RNA G-quadruplexes: Overview 50 years after their discovery
NG Dolinnaya, AM Ogloblina, MG Yakubovskaya - Biochemistry (Moscow), 2016 - Springer
Abstract G-quadruplexes (G4s), which are known to have important roles in regulation of key
biological processes in both normal and pathological cells, are the most actively studied non …
biological processes in both normal and pathological cells, are the most actively studied non …
Alternative splicing modulation by G-quadruplexes
I Georgakopoulos-Soares, GE Parada… - Nature …, 2022 - nature.com
Alternative splicing is central to metazoan gene regulation, but the regulatory mechanisms
are incompletely understood. Here, we show that G-quadruplex (G4) motifs are enriched~ 3 …
are incompletely understood. Here, we show that G-quadruplex (G4) motifs are enriched~ 3 …